Article
Mutational analysis on structure-function relationship of a holliday junction specific endonuclease RuvC.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 1998
Ichiyanagi K, Iwasaki H, Hishida T, Shinagawa H
Abstract excerpt
BACKGROUND: Escherichia coli RuvC protein is a specific endonuclease that resolves Holliday junctions during homologous recombination. For junction resolution, RuvC undergoes distinct steps such as dimerization, junction-specific binding and endonucleolytic cleavage. The crystal structure of RuvC...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- DNA
- Endodeoxyribonucleases
- Enzyme Stability
- Escherichia coli
- Escherichia coli Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- Protein Conformation
- Recombination, Genetic
- Structure-Activity Relationship
- Ultraviolet Rays