Article
Suppression of human anti-porcine T-cell immune responses by major histocompatibility complex class II transactivator constructs lacking the amino terminal domain.
Transplantation - 15 Jul 1998
Yun S, Gustafsson K, Fabre J W
Abstract excerpt
BACKGROUND: The class II transactivator (CIITA) is a bi- or multifunctional domain protein that acts as a transcriptional activator and plays a critical role in the expression of MHC class II genes. We have previously demonstrated that a mutated form of the human CIITA gene, coding for a protein...
Topics
- Amino Acid Sequence
- Animals
- Antibody Formation
- Antigens, Heterophile
- B-Lymphocytes
- Base Sequence
- Cell Line
- Endothelium, Vascular
- Gene Deletion
- Humans
- Interferon-gamma
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- RNA, Messenger
- Swine
- T-Lymphocytes
- Trans-Activators