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Article

Suppression of Human T-Cell Activation and Expansion of Regulatory T Cells by Pig Cells Overexpressing PD-Ligands

15 Apr 2009

Abstract excerpt

BACKGROUND: Genetic modification of pigs (e.g., transgenic expression of human complement regulatory molecules or inactivation of alpha1,3galactosyltransferase) enabled the development of promising strategies to overcome hyperacute rejection after pig-to-primate xenotransplantation. However, cellular rejection still remains a hurdle for successful xenograft survival. This report tested the hypothesis that...

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Share to Hematopoietic Stem Cell Transplantation
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PMID: 19352115
DOI: 10.1097/tp.0b013e31819c85e8

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