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Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expression

17 Mar 2010

Abstract excerpt

PURPOSE OF REVIEW: Appropriate expression of immunomodulatory and anticoagulant proteins on endothelial cells is essential to prevent rejection of vascularized porcine organs after transplantation into primates. Here, we review the promoter sequences used for the establishment of transgenic pigs, as organ donors for xenotransplantation. RECENT FINDINGS: Transgenic pigs were produced using viral, chicken, mouse,...

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PMID: 20061949
DOI: 10.1097/mot.0b013e328336ba4a

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