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Article

Functionally inactivating point mutation in the tumor-suppressorIRF-1 gene identified in human gastric cancer

12 Aug 1998

Abstract excerpt

Loss of heterozygosity (LOH) observed in human tumors strongly suggests the existence of (a) tumor-suppressor gene(s) at the concerned locus. A series of studies has revealed that LOH on the long arm of chromosome 5 (5q) frequently occurs in differentiated gastric adenocarcinomas. Furthermore, it has been shown that the interferon regulatory factor-1 (IRF-1) locus on chromosome 5q31.1 is one of the common minimal...

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PMID: 9679752
DOI: 10.1002/(sici)1097-0215(19980812)77:4<522::aid-ijc8>3.0.co;2-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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