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Article

Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma.

Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2002

Carvalho Ralph, Kayademir Tuncay, Soares Paula, Canedo Paulo, Sousa Sónia, Oliveira Carla, Leistenschneider Peter, Seruca Raquel, Gött Peter, Blin Nikolaus, Carneiro Fátima, Machado José Carlos

Abstract excerpt

It has been advanced that the trefoil factor (TFF) 1 gene is a candidate tumor-suppressor gene and may be involved in the development and/or progression of human gastric cancer. We aimed to clarify the putative role of TFF1 in gastric carcinogenesis. Ninety gastric carcinomas and eight gastric carcinoma-derived cell lines were screened for TFF1 mutations; subsets of the primary tumors and of the cell lines were...

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Source

Identifiers

PMID: 12379766
DOI: 10.1097/01.lab.0000029205.76632.a8

Genes

TFF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma.PMID 12379766Read ↗

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