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Article

Inactivating mutations of KILLER/DR5 gene in gastric cancers.

Gastroenterology - 1 Nov 2001

Park W S, Lee J H, Shin M S, Park J Y, Kim H S, Kim Y S, Park C H, Lee S K, Lee S H, Lee S N, Kim H, Yoo N J, Lee J Y

Abstract excerpt

BACKGROUND & AIMS: The KILLER/death receptor (DR)5 has been identified as a potent inducer of apoptosis, and mapped to chromosome 8p21-22, showing frequent allelic loss in gastric cancer. The p53-induced apoptosis is an important biological process to prevent the development of cancer, and is mediated in part by expression of KILLER/DR5 only in cells with wild-type p53 protein, but not in those lacking p53...

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Source

Identifiers

PMID: 11677215
DOI: 10.1053/gast.2001.28663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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