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Article

Somatic mutations of the trefoil factor family 1 gene in gastric cancer.

Gastroenterology - 1 Sept 2000

Park W S, Oh R R, Park J Y, Lee J H, Shin M S, Kim H S, Lee H K, Kim Y S, Kim S Y, Lee S H, Yoo N J, Lee J Y

Abstract excerpt

BACKGROUND & AIMS: There is increasing evidence that trefoil factor family 1 (TFF1) is a stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. TFF1 knockout mice developed multiple gastric adenomas and carcinomas, suggesting that TFF1 is a gastric-specific tumor-suppressor gene. METHODS: We analyzed the somatic mutations and loss of...

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Source

Identifiers

PMID: 10982763
DOI: 10.1053/gast.2000.16483

Genes

TFF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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