Article
Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme.
The Journal of cell biology - 27 Jul 1998
Vollenweider F, Kappeler F, Itin C, Hauri H P
Abstract excerpt
ERGIC-53, a homo-oligomeric recycling protein associated with the ER-Golgi intermediate compartment (ERGIC), has properties of a mannose-selective lectin in vitro, suggesting that it may function as a transport receptor for glycoproteins in the early secretory pathway. To investigate if ERGIC-53...
Topics
- Amino Acid Sequence
- Biological Transport, Active
- Cathepsin C
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Endoplasmic Reticulum, Rough
- Enzyme Precursors
- Gene Expression
- Glycoproteins
- Golgi Apparatus
- HeLa Cells
- Humans
- Lectins
- Lysosomes
- Mannose-Binding Lectins
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Transformation, Genetic