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Article

Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme.

The Journal of cell biology - 27 Jul 1998

Vollenweider F, Kappeler F, Itin C, Hauri H P

Abstract excerpt

ERGIC-53, a homo-oligomeric recycling protein associated with the ER-Golgi intermediate compartment (ERGIC), has properties of a mannose-selective lectin in vitro, suggesting that it may function as a transport receptor for glycoproteins in the early secretory pathway. To investigate if ERGIC-53 is involved in glycoprotein secretion, a mutant form of this protein was generated that is incapable of leaving the ER....

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Identifiers

PMID: 9679138
DOI: 10.1083/jcb.142.2.377
PMCID: PMC2133042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme.PMID 9679138Read ↗

ERGIC-53 and traffic in the secretory pathwaySemantic proximity Read ↗

Regulation of Mac-2BP secretion is mediated by its N-glycan binding to ERGIC-53.Semantic proximity Read ↗

ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins.Semantic proximity Read ↗

Oligomerization and interacellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds.Semantic proximity Read ↗

Carbohydrate- and conformation-dependent cargo capture for ER-exit.Semantic proximity Read ↗

ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains.Semantic proximity Read ↗

[Transport mechanism of glycoproteins by ERGIC-53 and the disease caused by defect in a gene coding ERGIC-53].Semantic proximity Read ↗

Transient dimerization and interaction with ERGIC-53 occur in the fibroblast growth factor receptor 3 early secretory pathway.Semantic proximity Read ↗

Biosynthesis of lysosomal enzymes in cells of the End3 complementation group conditionally defective in endosomal acidification.Semantic proximity Read ↗

Selective delivery of secretory cargo in Golgi-derived carriers of nonepithelial cells.Semantic proximity Read ↗

Wild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Isolation of a temperature-sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment.Semantic proximity Read ↗

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