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Article

Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein.

The Journal of biological chemistry - 31 Jul 1998

Liang S H, Hong D, Clarke M F

Abstract excerpt

Cytoplasmic sequestration of the p53 tumor suppresser protein has been proposed as a mechanism involved in abolishing p53 function. However, the mechanisms regulating p53 subcellular localization remain unclear. In this report, we analyzed the possible existence of cis-acting sequences involved in intracellular trafficking of the p53 protein. To study p53 trafficking, the jellyfish green fluorescent protein (GFP)...

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Identifiers

PMID: 9677415
DOI: 10.1074/jbc.273.31.19817

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein.PMID 9677415Read ↗

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The requirement of the carboxyl terminus of p53 for DNA binding and transcriptional activation depends on the specific p53 binding DNA element.Semantic proximity Read ↗

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.Semantic proximity Read ↗

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