Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein.

doi:10.1074/jbc.273.31.19817

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Article

Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein.

The Journal of biological chemistry - 31 Jul 1998

Liang S H, Hong D, Clarke M F

Abstract excerpt

Cytoplasmic sequestration of the p53 tumor suppresser protein has been proposed as a mechanism involved in abolishing p53 function. However, the mechanisms regulating p53 subcellular localization remain unclear. In this report, we analyzed the possible existence of cis-acting sequences involved i...

Topics

Amino Acid Sequence
Cell Nucleus
Conserved Sequence
Cytoplasm
Gene Expression Regulation, Neoplastic
Genes, Reporter
Green Fluorescent Proteins
Humans
Luminescent Proteins
Microscopy, Fluorescence
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Mutation

Recombinant Fusion Proteins

Transfection

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9677415
DOI: 10.1074/jbc.273.31.19817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9677415-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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