p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer.

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Article

p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 1998

Brambilla E, Gazzeri S, Lantuejoul S, Coll J L, Moro D, Negoescu A, Brambilla C

Abstract excerpt

Lung cancer is the end result of a multistep process in which genetic and molecular changes accompany, in an unknown temporal sequence, histological precursor (preinvasive) bronchial lesions. Biomarkers allowing prediction of the rate of progression of precursor lesions at different locations in...

Topics

Bronchial Neoplasms
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Genes, p53
Humans
Immunophenotyping
Lung Neoplasms
Mutation
Neoplasm Invasiveness
Neoplasm Proteins
Precancerous Conditions
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9676834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9676834-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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bcl-2-Associated X Protein