A correlation between mutation of the p53 gene and histological heterogeneity in differentiated adenocarcinomas of the lung, with reference to stepwise progression and metastatic ability.

Abstract excerpt

I examined 15 cases of differentiated adenocarcinoma of the lung which showed mutation of the p53 gene and whose primary lesions could be divided into three components (peripheral component, intermediate component and central component). Mutation of the p53 gene in each component was examined by...

Topics

• Adenocarcinoma
• Adult
• Aged
• Base Sequence
• DNA, Neoplasm
• Female
• Genes, p53
• Humans
• Ki-67 Antigen
• Lung Neoplasms
• Male
• Middle Aged
• Molecular Sequence Data