Article
Functional PAX-6 gene-linked polymorphic region: potential association with paranoid schizophrenia.
Biological psychiatry - 15 Jun 1999
Stöber G, Syagailo Y V, Okladnova O, Jungkunz G, Knapp M, Beckmann H, Lesch K P
Abstract excerpt
BACKGROUND: Early differentiation of the nervous system and adult CNS neuroplasticity is modulated by PAX-6. We have shown previously that a highly polymorphic, functional AC/AG repeat in the 5' regulatory region of the gene showed significantly increased promoter activity, if containing > or = 29 repeats, and that the heterozygous genotype (< or = 28/> or = 29) revealed increased mRNA PAX-6 levels in human brain...
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