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Article

Iron deficiency-induced tetracycline production in submerged cultures by Streptomyces aureofaciens.

Journal of applied microbiology - 1 May 1998

Béchet M, Blondeau R

Abstract excerpt

Streptomyces aureofaciens ATCC 10762 grown in rotary-shaken submerged cultures produced substantial amounts of tetracycline only when the defined medium was deprived of iron. The biosynthesis of tetracycline was inhibited either by free iron at concentrations above 1-2 mumol l-1, or by chelated iron provided by the siderophores of this bacterial strain. Late static iron-containing cultures allowed cell...

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PMID: 9674144
DOI: 10.1046/j.1365-2672.1998.00428.x

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