Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.

Infection and immunity - 1 Aug 1998

Zhang J R, Norris S J

Abstract excerpt

The Lyme disease spirochete Borrelia burgdorferi possesses 15 silent vls cassettes and a vls expression site (vlsE) encoding a surface-exposed lipoprotein. Segments of the silent vls cassettes have been shown to recombine with the vlsE cassette region in the mammalian host, resulting in combinatorial antigenic variation. Despite promiscuous recombination within the vlsE cassette region, the 5' and 3' coding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Base Sequence
Share to DNA, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Bacterial

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 9673251
DOI: 10.1128/IAI.66.8.3698-3704.1998
PMCID: PMC108404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.PMID 9673251Read ↗

vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity.Semantic proximity Read ↗

Changing of the guard: How the Lyme disease spirochete subverts the host immune response.Semantic proximity Read ↗

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.Semantic proximity Read ↗

Detailed Analysis of Sequence Changes Occurring during vlsE Antigenic Variation in the Mouse Model of Borrelia burgdorferi InfectionSemantic proximity Read ↗

Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.Semantic proximity Read ↗

Breaking a barrier: In trans vlsE recombination and genetic manipulation of the native vlsE gene of the Lyme disease pathogenSemantic proximity Read ↗

Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle.Semantic proximity Read ↗

‘Nothing is permanent but change’†- antigenic variation in persistent bacterial pathogensSemantic proximity Read ↗

Lack of detectable variation at Borrelia burgdorferi vlsE locus in ticks.Semantic proximity Read ↗

Variable VlsE is critical for host reinfection by the Lyme disease spirochete.Semantic proximity Read ↗

Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.Semantic proximity Read ↗

Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.