Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.

doi:10.1128/IAI.66.8.3698-3704.1998

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Article

Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.

Infection and immunity - 1 Aug 1998

Zhang J R, Norris S J

Abstract excerpt

The Lyme disease spirochete Borrelia burgdorferi possesses 15 silent vls cassettes and a vls expression site (vlsE) encoding a surface-exposed lipoprotein. Segments of the silent vls cassettes have been shown to recombine with the vlsE cassette region in the mammalian host, resulting in combinato...

Topics

Animals
Antigens, Bacterial
Antigens, Surface
Bacterial Proteins
Base Sequence
Borrelia burgdorferi Group
DNA, Bacterial
Disease Models, Animal
Gene Conversion
Genes, Bacterial
Genetic Variation
Lipoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lyme Disease

Mice

Mice, Inbred C3H

Molecular Sequence Data

Multigene Family

Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 9673251
DOI: 10.1128/IAI.66.8.3698-3704.1998
PMCID: PMC108404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9673251-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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