Article
Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.
PloS one - 1 Jan 2015
Rogovskyy Artem S, Casselli Timothy, Tourand Yvonne, Jones Cami R, Owen Jeb P, Mason Kathleen L, Scoles Glen A, Bankhead Troy
Abstract excerpt
Efficient acquisition and transmission of Borrelia burgdorferi by the tick vector, and the ability to persistently infect both vector and host, are important elements for the life cycle of the Lyme disease pathogen. Previous work has provided strong evidence implicating the significance of the vls locus for B. burgdorferi persistence. However, studies involving vls mutant clones have thus far only utilized in...
Topics
- Animals
- Antigenic Variation
- Antigens, Bacterial
- Bacterial Proteins
- Borrelia burgdorferi
- Ixodes
- Lipoproteins
- Lyme Disease
- Mice
- Mice, Inbred C3H
- Mice, SCID