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Article

Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle.

Journal of bacteriology - 1 Aug 2003

Ohnishi Jun, Schneider Brad, Messer William B, Piesman Joseph, de Silva Aravinda M

Abstract excerpt

The Lyme disease spirochete, Borrelia burgdorferi, causes a persistent infection in the vertebrate host even though infected animals mount an active immune response against the spirochete. One strategy used by the spirochete to evade vertebrate host immunity is to vary the structure and expression of outer membrane antigens. The vlsE locus represents the best-studied example of antigenic variation in B....

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Identifiers

PMID: 12867452
DOI: 10.1128/JB.185.15.4432-4441.2003
PMCID: PMC165742

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle.PMID 12867452Read ↗

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Detailed Analysis of Sequence Changes Occurring during vlsE Antigenic Variation in the Mouse Model of Borrelia burgdorferi InfectionSemantic proximity Read ↗

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Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.Semantic proximity Read ↗

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