Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.

PLoS pathogens - 1 Dec 2009

Lin Tao, Gao Lihui, Edmondson Diane G, Jacobs Mary B, Philipp Mario T, Norris Steven J

Abstract excerpt

Antigenic variation plays a vital role in the pathogenesis of many infectious bacteria and protozoa including Borrelia burgdorferi, the causative agent of Lyme disease. VlsE, a 35 kDa surface-exposed lipoprotein, undergoes antigenic variation during B. burgdorferi infection of mammalian hosts, and is believed to be a critical mechanism by which the spirochetes evade immune clearance. Random, segmental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to Borrelia burgdorferi

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Helicases

Share to DNA Transposable Elements

Share to Genetic Complementation Test

Share to Ixodes

Share to Lipoproteins

Share to Mice, SCID

Source

Open in PubMed Open full text

Identifiers

PMID: 19997622
DOI: 10.1371/journal.ppat.1000679
PMCID: PMC2780311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.PMID 19997622Read ↗

Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase.Semantic proximity Read ↗

vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity.Semantic proximity Read ↗

Detailed Analysis of Sequence Changes Occurring during vlsE Antigenic Variation in the Mouse Model of Borrelia burgdorferi InfectionSemantic proximity Read ↗

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.Semantic proximity Read ↗

Changing of the guard: How the Lyme disease spirochete subverts the host immune response.Semantic proximity Read ↗

Variable VlsE is critical for host reinfection by the Lyme disease spirochete.Semantic proximity Read ↗

Breaking a barrier: In trans vlsE recombination and genetic manipulation of the native vlsE gene of the Lyme disease pathogenSemantic proximity Read ↗

Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle.Semantic proximity Read ↗

Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.Semantic proximity Read ↗

Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.Semantic proximity Read ↗

Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosa.Semantic proximity Read ↗

Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.