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Article

Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism.

Archives of general psychiatry - 1 Jan 1994

Nielsen D A, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M

Abstract excerpt

BACKGROUND: To examine whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme in the biosynthesis of serotonin, may be a factor influencing serotonin turnover and behaviors controlled by serotonin. METHODS: Using a polymerase chain reaction-based method, TPH genotype was determined in DNA samples from 56 impulsive and 14 nonimpulsive, alcoholic, violent offenders and 20 healthy...

Topics

Adult
Alcoholism
Antisocial Personality Disorder
Disruptive, Impulse Control, and Conduct Disorders
Genotype
Humans
Hydroxyindoleacetic Acid
Male
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serotonin

Suicide

Suicide, Attempted

Tryptophan Hydroxylase

Violence

Source

Identifiers

PMID: 7506517
DOI: 10.1001/archpsyc.1994.03950010034005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7506517-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism.PMID 7506517Read ↗

A tryptophan hydroxylase gene marker for suicidality and alcoholism.Semantic proximity Read ↗

Identification of four variants in the tryptophan hydroxylase promoter and association to behavior.Semantic proximity Read ↗

Increased risk of suicide attempt in mood disorders and TPH1 genotype.Semantic proximity Read ↗

Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes.Semantic proximity Read ↗

A dimensional impulsive-aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: a pilot study in well-characterized impulsive inpatients.Semantic proximity Read ↗

Genetics of the serotonergic system in suicidal behavior.Semantic proximity Read ↗

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

Serotonergic genes and suicide: a systematic review.Semantic proximity Read ↗

Association of anger-related traits with SNPs in the TPH gene.Semantic proximity Read ↗

The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH 2) single nucleotide polymorphisms, suicide, and alcohol-related suicide.Semantic proximity Read ↗

Association between the tryptophan hydroxylase gene and manic-depressive illness.Semantic proximity Read ↗

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