Article
The role of p53 and cell death by apoptosis and necrosis in 4-hydroperoxycyclophosphamide-induced limb malformations.
Development (Cambridge, England) - 1 Aug 1998
Moallem S A, Hales B F
Abstract excerpt
The exposure of embryonic murine limbs in vitro to an activated analog of cyclophosphamide, 4-hydroperoxycyclophosphamide (4OOH-CPA), induced limb malformations and apoptosis. The purpose of this study was to investigate the role of the tumor suppressor/cell cycle checkpoint gene, p53, and of cel...
Topics
- Animals
- Apoptosis
- Cell Cycle
- Cyclophosphamide
- DNA Fragmentation
- Embryo, Mammalian
- Extremities
- Flow Cytometry
- Gene Expression Regulation, Developmental
- Genes, p53
- Genotype
- Heterozygote
- Histocytochemistry
- Mice
- Mice, Knockout
- Microscopy, Electron
- Necrosis
- Poly(ADP-ribose) Polymerases