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Article

Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage.

Oncogene - 3 Jul 2008

Chae H D, Kim B M, Yun U J, Shin D Y

Abstract excerpt

We previously reported that actin damage by treatment with an actin-depolymerizing agent including pectenotoxin-2 induces Bim-mediated apoptosis in p53-deficient human tumors. In this study, we investigated a molecular mechanism underlying Bim-mediated apoptosis of p53-deficient tumor cells following actin damage. We found that actin inhibitors increased the protein levels of p53 and p21 and thereby inactivated...

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Identifiers

PMID: 18345036
DOI: 10.1038/onc.2008.46

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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