Article
Morphological analysis of abnormal digital chondrogenesis in the brachypod (bpH) mouse limb in organ culture.
Anatomy and embryology - 1 Jan 1992
Kwasigroch T E, Curtis S K, Knudsen T B, Barrach H J, Elmer W A
Abstract excerpt
Brachypod (bpH/bpH), an autosomal mutation in mice, is characterized by a shortening of the long bones and paws, and a delay or absence of ossification in some of the distal limb elements. The present study represents a detailed description of the brachypod phenotype in day 12 hindlimb buds maintained for 6 days in a submerged, serum-free organ culture system. Using this in vitro system, the proximal-to-distal...
Topics
- Animals
- Cartilage
- Collagen
- Extremities
- Glycogen
- Hindlimb
- Humans
- Immunohistochemistry
- Intercellular Junctions
- Mice
- Mice, Mutant Strains
- Organ Culture Techniques