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Endothelin signaling in development

11 Dec 2023

Abstract excerpt

Since the discovery of endothelin 1 (EDN1) in 1988, the role of endothelin ligands and their receptors in the regulation of blood pressure in normal and disease states has been extensively studied. However, endothelin signaling also plays crucial roles in the development of neural crest cell-derived tissues. Mechanisms of endothelin action during neural crest cell maturation have been deciphered using a variety...

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PMID: 38078652
DOI: 10.1242/dev.201786

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