Chain-terminating mutations in the APC gene lead to alterations in APC RNA and protein concentration.

Abstract excerpt

APC mutations introduce premature stop codons into the open reading frame of the gene, leading to the formation of truncated tumor suppressor proteins. Both RNA and protein levels are likely to be profoundly altered by such nonsense mutations. To test this hypothesis, Western blotting and RT-PCR strategies were used to characterize mutant and normal APC protein and APC RNA concentrations in lymphoblastoid cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adolescent
• Share to Alternative Splicing