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Article

Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.

Human genetics - 1 Dec 1996

van der Luijt R B, Meera Khan P, Vasen H F, Breukel C, Tops C M, Scott R J, Fodde R

Abstract excerpt

Familial adenomatous polyposis (FAP) is an inherited predisposition to colorectal cancer characterized by the development of numerous adenomatous polyps predominantly in the colorectal region. Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for most cases of FAP. Mutations at the 5' end of APC are known to be associated with a relatively mild form of the disease, called attenuated...

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Source

Identifiers

PMID: 8931709
DOI: 10.1007/s004390050293

Genes

APC
FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.PMID 8931709Read ↗

Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein.Semantic proximity Read ↗

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Seven novel mutations in the APC gene of Portuguese families with familial adenomatous polyposis: correlation with phenotype.Semantic proximity Read ↗

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Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15.Semantic proximity Read ↗

Alleles of the APC gene: an attenuated form of familial polyposis.Semantic proximity Read ↗

A new germline stop codon mutation in exon 15 of the APC gene predisposing to familial adenomatous polyposis.Semantic proximity Read ↗

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