Article
Detection of APC gene deletion by double competitive polymerase chain reaction in patients with familial adenomatous polyposis.
International journal of oncology - 1 Aug 2006
Takahashi Maho, Kikuchi Mariko, Ohkura Naganari, Yaguchi Hiroko, Nagamura Yuko, Ohnami Sumiko, Ushiama Mineko, Yoshida Teruhiko, Sugano Kokichi, Iwama Takeo, Kosugi Shinji, Tsukada Toshihiko
Abstract excerpt
Familial adenomatous polyposis (FAP) is an autosomal dominant familial cancer syndrome caused by germline mutations of the tumor suppressor adenomatous polyposis coli (APC) gene. Heterozygous apc mutations have been identified in the majority of classical FAP patients who develop more than 100 colorectal adenomas. However, classical FAP patients often fail to display germline APC mutations detectable by routine...
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