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Article

Attenuated APC alleles produce functional protein from internal translation initiation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2002

Heppner Goss Kathleen, Trzepacz Chris, Tuohy Thérèse M F, Groden Joanna

Abstract excerpt

Some truncating mutations of the APC tumor suppressor gene are associated with an attenuated phenotype of familial adenomatous polyposis coli (AAPC). This work demonstrates that APC alleles with 5' mutations produce APC protein that down-regulates beta-catenin, inhibits beta-catenin/T cell factor-mediated transactivation, and induces cell-cycle arrest. Transfection studies demonstrate that cap-independent...

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Share to Adenomatous Polyposis Coli Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 12034871
DOI: 10.1073/pnas.112072199
PMCID: PMC123038

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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