Article
Multiple sclerosis: the increased frequency of the ICAM-1 exon 6 gene point mutation genetic type K469.
Annals of neurology - 1 Jul 1998
Mycko M P, Kwinkowski M, Tronczynska E, Szymanska B, Selmaj K W
Abstract excerpt
Intracellular adhesion molecule-1 (ICAM-1) plays an important role in the cascade of adhesion events in the homing of inflammatory cells to the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE) and in multiple sclerosis (MS). Two single-base ICAM-1 polymorphisms have...
Topics
- Base Sequence
- Case-Control Studies
- Chi-Square Distribution
- DNA
- Gene Frequency
- Genetic Linkage
- Genetic Testing
- Genotype
- Humans
- Intercellular Adhesion Molecule-1
- Magnetic Resonance Imaging
- Multiple Sclerosis
- Point Mutation
- Polymorphism, Genetic
- Random Allocation
- Reference Values
- White People