Article
Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Neurobiology of disease - 1 Apr 1998
Thinakaran G, Regard J B, Bouton C M, Harris C L, Price D L, Borchelt D R, Sisodia S S
Abstract excerpt
Mutations in two related genes, presenilin 1 and 2 presenilin 2 (PS1 and PS2), cosegregate with Alzheimer's disease. PS1 and PS2 are highly homologous polytopic membrane proteins that are subject to endoproteolytic cleavage in vivo. The resulting N- and C-terminal derivatives are the preponderant...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Detergents
- Epitopes
- Membrane Proteins
- Mice
- Mutation
- Neuroblastoma
- Peptide Fragments
- Polyethylene Glycols
- Precipitin Tests