Article
Subcellular distribution and turnover of presenilins in transfected cells.
The Journal of biological chemistry - 15 May 1998
Zhang J, Kang D E, Xia W, Okochi M, Mori H, Selkoe D J, Koo E H
Abstract excerpt
The mechanisms by which mutations in presenilin-1 (PS1) and presenilin-2 (PS2) result in the Alzheimer's disease phenotype are unclear. Full-length PS1 and PS2 are each processed into stable proteolytic fragments after their biosynthesis in transfected cells. PS1 and PS2 have been localized by im...
Topics
- Animals
- CHO Cells
- Cricetinae
- Immunohistochemistry
- Membrane Proteins
- Mutation
- Presenilin-1
- Presenilin-2
- Subcellular Fractions
- Transfection
- Triiodobenzoic Acids