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Article

Subcellular distribution and turnover of presenilins in transfected cells.

The Journal of biological chemistry - 15 May 1998

Zhang J, Kang D E, Xia W, Okochi M, Mori H, Selkoe D J, Koo E H

Abstract excerpt

The mechanisms by which mutations in presenilin-1 (PS1) and presenilin-2 (PS2) result in the Alzheimer's disease phenotype are unclear. Full-length PS1 and PS2 are each processed into stable proteolytic fragments after their biosynthesis in transfected cells. PS1 and PS2 have been localized by immunocytochemistry to the endoplasmic reticulum (ER) and Golgi compartments, but previous studies could not...

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Identifiers

PMID: 9575200
DOI: 10.1074/jbc.273.20.12436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Subcellular distribution and turnover of presenilins in transfected cells.PMID 9575200Read ↗

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Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine TissuesSemantic proximity Read ↗

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