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Article

Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes.

Experimental cell research - 10 Jul 1998

Smith M L, Bortnick R A, Sheikh M S, Fornace A J

Abstract excerpt

In this study, using a cell line that carries endogenous wild-type p53 genes, we show that transfection of cells with mutant p53, HPV16-E6, or cyclin G transgenes results in the disruption of higher-order chromatin structure, as evidenced by enhanced sensitivity to micrococcal nuclease. Multiple mechanisms may contribute to this phenotype, including histone H1 phosphorylation, direct binding of oncoproteins to...

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Identifiers

PMID: 9665821
DOI: 10.1006/excr.1998.4078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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