Article
Critical roles of the cAMP-responsive element-binding protein-mediated pathway in disorganized epithelial phenotypes caused by mitochondrial dysfunction.
Cancer science - 1 Oct 2012
Shibanuma Motoko, Ishikawa Fumihiro, Kobayashi Masayuki, Katayama Kazufumi, Miyoshi Hiroyuki, Wakamatsu Masami, Mori Kazunori, Nose Kiyoshi
Abstract excerpt
In most human cancers, somatic mutations have been identified in the mtDNA; however, their significance remains unclear. We recently discovered that NMuMG mouse mammary epithelial cells, when deprived of mitochondria or following inhibition of respiratory activity, undergo epithelial morphological disruption accompanied with irregular edging of E-cadherin, the appearance of actin stress fibers, and an altered...
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