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Article

Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study

30 Nov 2011

Abstract excerpt

AIMS: Epidermal growth factor receptor (EGFR) gene copy number evaluated by fluorescence in situ hybridisation (FISH) can discriminate among KRAS wild-type patients those with better outcome to EGFR-targeted therapy in metastatic colorectal cancer, further enhancing selection of patients. Nevertheless, enumeration of gene copies is challenging and the lack of analytical standardisation has limited incorporation...

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PMID: 22130903
DOI: 10.1136/jclinpath-2011-200353

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