Article
Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line.
International journal of oncology - 1 Aug 1998
Grandis J R, Zeng Q, Drenning S D, Tweardy D J
Abstract excerpt
Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by mutation of the p53 tumor suppressor gene and increased expression of the epidermal growth factor receptor (EGFR). To determine the potential link between p53 and EGFR expression, we examined the effect of overexpressing...
Topics
- Blotting, Northern
- Carcinoma, Squamous Cell
- Down-Regulation
- ErbB Receptors
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Mutation
- RNA, Messenger
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- Up-Regulation