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Article

Small deletions but not methylation underlie <i>CDKN2A/p16</i> loss of expression in conventional osteosarcoma

24 Aug 2010

Abstract excerpt

Conventional osteosarcoma is characterized by rapid growth, high local aggressiveness, and metastasizing potential. Patients developing lung metastases experience poor prognosis despite extensive chemotherapy regimens and surgical interventions. Previously we identified a subgroup of osteosarcoma patients with loss of CDKN2A/p16 protein expression in the primary tumor biopsies which was significantly predictive...

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Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
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PMID: 20737480
DOI: 10.1002/gcc.20817

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