Article
SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. II. Changes in gap junctional intercellular communication.
International journal of cancer - 29 Jul 1998
Khoo N K, Zhang Y, Bechberger J F, Bond S L, Hum K, Lala P K
Abstract excerpt
Poor gap junctional intercellular communication (GJIC) has been associated with uncontrolled cell growth and neoplasia. We have successfully propagated normal first trimester invasive extravillous trophoblast (EVT) cells, and have produced premalignant EVT lines after SV40 Tag transformation: RSV...
Topics
- Analysis of Variance
- Antigens, Viral, Tumor
- Cell Communication
- Cell Transformation, Neoplastic
- Connexin 26
- Connexin 43
- Connexins
- Female
- Gap Junctions
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasm Invasiveness
- Phenotype
- Precancerous Conditions