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TGF-β1 up-regulates connexin43 expression: A potential mechanism for human trophoblast cell differentiation

5 Jan 2015

Abstract excerpt

Connexin43 (Cx43)-mediated gap junctional intercellular communication (GJIC) are required for human trophoblast differentiation. To date, whether Cx43 mediates TGF-β1-induced trophoblast differentiation has not been determined. We showed that treatment with TGF-β1 increased Cx43 expression and GJIC in HTR-8/SVneo human trophoblast cells. In addition, Smad and ERK1/2 signaling pathways were involved in...

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PMID: 25560303
DOI: 10.1002/jcp.24902

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