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Article

HER1 Signaling Mediates Extravillous Trophoblast Differentiation in Humans1

26 Aug 2010

Abstract excerpt

This study examines the role of HER1 signaling in the differentiation of proliferative extravillous trophoblast (EVT) into invasive EVT. Using the JAR choriocarcinoma cell line and placental villous explants as experimental models and immunohistochemical assessment of protein markers of EVT differentiation (downregulation of HER1 and Cx40 and upregulation of HER2 and alpha1 integrin), we show that the ability of...

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PMID: 20739666
DOI: 10.1095/biolreprod.109.083246

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