Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human placental trophoblast as an in vitro model for tumor progression

1 Feb 2002

Abstract excerpt

The human placenta is a highly invasive tumor-like structure in which a subpopulation of placental trophoblast cells known as the "extravillous trophoblast" (EVT) invades the uterine decidua and its vasculature to establish adequate fetal-maternal exchange of molecules. By utilizing in vitro-propagated short-lived EVT cell lines we found that molecular mechanisms responsible for their invasiveness are identical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pregnancy and preeclampsia studies
Share to Renal and related cancers
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11934257
DOI: 10.1139/y02-006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human placental trophoblast as an in vitro model for tumor progressionPMID 11934257Read ↗

SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasiveness and resistance to anti-invasive action of TGFbeta.Semantic proximity Read ↗

Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta†Semantic proximity Read ↗

Trophoblast 'pseudo-tumorigenesis': Significance and contributory factorsSemantic proximity Read ↗

Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1).Semantic proximity Read ↗

Investigation of human trophoblast invasion in vitroSemantic proximity Read ↗

HER1 Signaling Mediates Extravillous Trophoblast Differentiation in Humans1Semantic proximity Read ↗

SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. II. Changes in gap junctional intercellular communication.Semantic proximity Read ↗

Establishment of an immortalized human extravillous trophoblast cell line by retroviral infection of E6/E7/hTERT and its transcriptional profile during hypoxia and reoxygenation.Semantic proximity Read ↗

Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placentaSemantic proximity Read ↗

Shifting perspectives from “oncogenic” to oncofetal proteins; how these factors drive placental developmentSemantic proximity Read ↗

Autocrine-Paracrine Regulation of Human Trophoblast Invasiveness by Insulin-like Growth Factor (IGF)-II and IGF-Binding Protein (IGFBP)-1Semantic proximity Read ↗

Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.