Plasminogen mutants activated by thrombin. Potential thrombus-selective thrombolytic agents.

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Article

Plasminogen mutants activated by thrombin. Potential thrombus-selective thrombolytic agents.

The Journal of biological chemistry - 10 Jun 1994

Dawson K M, Cook A, Devine J M, Edwards R M, Hunter M G, Raper R H, Roberts G

Abstract excerpt

Plasmin, the enzyme responsible for degradation of fibrin in blood clots and thus thrombolysis, is normally formed when its zymogen plasminogen is activated by cleavage of the Arg561-Val562 bond by specific plasminogen activators. We have altered the activation characteristics of plasminogen by s...

Topics

Amino Acid Sequence
Base Sequence
Enzyme Activation
Factor XI
Factor XIII
Fibrinogen
Fibrinolysin
Fibrinolytic Agents
Humans
Molecular Sequence Data
Mutation
Plasminogen
Protein Processing, Post-Translational
Receptors, Thrombin
Recombinant Proteins
Thrombin

Source

Open in PubMed

Identifiers

PMID: 8206894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8206894-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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