Article

Low-Intensity Ultrasound Lysis of Amyloid Microclots in a Lab-on-Chip Model

2025-03-13

Abstract excerpt

Amyloid fibrin(ogen) microclots are misfolded protein aggregates with β-sheet structures that have been associated with Long COVID and numerous thrombo-inflammatory diseases. These microclots persist in circulation and obstruct microvasculature, impair oxygen transport and promote chronic inflammation. Conventional thrombolytic therapies such as recombinant tissue plasminogen activator (rtPA) show limited efficacy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd6a2d9e-fbd0-5dab-abac-5281e98cb384
DOI: 10.1101/2025.03.10.642458

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low-Intensity Ultrasound Lysis of Amyloid Microclots in a Lab-on-Chip ModelDOI 10.1101/2025.03.10.642458Read

The clots removed from ischaemic stroke patients by mechanical thrombectomy are amyloid in natureSemantic proximity Read

Inflammatory Triggers, Cell Death, Membrane Damage and Lipid Asymmetry That Shape Procoagulant Surfaces for Amyloidogenic MicroclottingSemantic proximity Read

Investigating the two regimes of fibrin clot lysis: an experimental and computational approachSemantic proximity Read

Shock-Scattering Micro-Histotripsy-Aided Fine Needle Aspiration for Enhanced Biomarker Profiling and CytopathologySemantic proximity Read

Untangling Covid-19 Pathophysiology Part I: Oligomeric (Soluble) Fibrin Forming Transient Microclots Enhances the Lethality of Covid-19Semantic proximity Read

Patient-specific "Physical Twin" artery-on-chip platform reveals complex flow-dependent VWF mechanobiology and guides personalized antithrombotic therapySemantic proximity Read

Microclots in Post‑COVID Condition: Clinical and Biomarker Response to Triple Antithrombotic Therapy. A Case ReportSemantic proximity Read

Acute induction of anomalous blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide (LPS)Semantic proximity Read

Micro- and Nanoplastics in Cardiovascular Toxicology: Human Tissue Detection, Clinical Phenotypes, and Adverse Outcome Signals.Semantic proximity Read

Combining Sonodynamic Therapy with Nanocarriers: Enhancing Treatment Targeting and EfficacySemantic proximity Read

Proteomic evidence for amyloidogenic cross-seeding in fibrinaloid microclotsSemantic proximity Read

Microbubble-Induced Acoustic Softening in Human Blood: A Pilot Translational Study Toward Understanding Unexplained Sudden Cardiac CollapseSemantic proximity Read