Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein.

doi:10.1359/jbmr.1998.13.7.1084

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Article

Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 1998

Motomura T, Kasayama S, Takagi M, Kurebayashi S, Matsui H, Hirose T, Miyashita Y, Yamauchi-Takihara K, Yamamoto T, Okada S, Kishimoto T

Abstract excerpt

The McCune-Albright syndrome (MAS) is characterized by polyostotic fibrous dysplasia, café-au-lait spots, and multiple endocrine hyperfunction. An activating missense mutation of the alpha subunit of the Gs protein (Gs alpha) was found in several affected tissues, resulting in prolonged stimulati...

Topics

3T3 Cells
Animals
Cell Line
Cyclic AMP
Disease Models, Animal
Fibrous Dysplasia, Polyostotic
GTP-Binding Proteins
Gene Expression Regulation
Interleukin-6
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

NF-kappa B

Osteoblasts

Promoter Regions, Genetic

Transcription Factor AP-1

Transcription Factors

Transfection

Source

Open in PubMed

Identifiers

PMID: 9661072
DOI: 10.1359/jbmr.1998.13.7.1084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9661072-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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