Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 1998

Motomura T, Kasayama S, Takagi M, Kurebayashi S, Matsui H, Hirose T, Miyashita Y, Yamauchi-Takihara K, Yamamoto T, Okada S, Kishimoto T

Abstract excerpt

The McCune-Albright syndrome (MAS) is characterized by polyostotic fibrous dysplasia, café-au-lait spots, and multiple endocrine hyperfunction. An activating missense mutation of the alpha subunit of the Gs protein (Gs alpha) was found in several affected tissues, resulting in prolonged stimulation of adenylate cyclase. Our recent study has indicated that the cells derived from the fibrous bone dysplasia tissues...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Mutation

Share to Promoter Regions, Genetic

Share to Transcription Factors

Share to Transfection

Source

Identifiers

PMID: 9661072
DOI: 10.1359/jbmr.1998.13.7.1084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein.PMID 9661072Read ↗

Cellular and molecular basis of fibrous dysplasia.Semantic proximity Read ↗

The CREB–Smad6–Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of boneSemantic proximity Read ↗

An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome.Semantic proximity Read ↗

Activating mutations of Gs protein in monostotic fibrous lesions of bone.Semantic proximity Read ↗

Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.Semantic proximity Read ↗

Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy.Semantic proximity Read ↗

Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.Semantic proximity Read ↗

Activating Gs(alpha) mutation in intramuscular myxomas with and without fibrous dysplasia of bone.Semantic proximity Read ↗

GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation.Semantic proximity Read ↗

Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS.Semantic proximity Read ↗

Transcriptional Regulation of the Mouse IL-7 Receptor α Promoter by Glucocorticoid ReceptorSemantic proximity Read ↗

CD73-generated adenosine promotes osteoblast differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.