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Article

Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.

The New England journal of medicine - 12 Dec 1991

Weinstein L S, Shenker A, Gejman P V, Merino M J, Friedman E, Spiegel A M

Abstract excerpt

BACKGROUND: The McCune-Albright syndrome is a sporadic disease characterized by polyostotic fibrous dysplasia, café au lait spots, sexual precocity, and hyperfunction of multiple endocrine glands. These manifestations may be explained by a somatic mutation in affected tissues that results in activation of the signal-transduction pathway generating cyclic AMP (cAMP). We analyzed DNA from tissues of patients with...

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PMID: 1944469
DOI: 10.1056/NEJM199112123252403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.PMID 1944469Read ↗

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