Article
CD73-generated adenosine promotes osteoblast differentiation.
Journal of cellular physiology - 1 Jun 2012
Takedachi Masahide, Oohara Hiroyuki, Smith Brenda J, Iyama Mitsuyoshi, Kobashi Mariko, Maeda Kenichiro, Long Courtney L, Humphrey Mary B, Stoecker Barbara J, Toyosawa Satoru, Thompson Linda F, Murakami Shinya
Abstract excerpt
CD731 is a GPI-anchored cell surface protein with ecto-5'-nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73-generated adenosine in bone tissue are largely unknown. To address this issue, we first analyzed the bone phenotype of CD73-deficient...
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