Article
Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia.
Blood - 1 Dec 2000
Bevan S, Catovsky D, Matutes E, Antunovic P, Auger M J, Ben-Bassat I, Bell A, Berrebi A, Gaminara E J, Júnior M E, Mauro F R, Quabeck K, Rassam S M, Reid C, Ribeiro I, Stark P, van Dongen J J, Wimperis J, Wright S, Marossy A, Yuille M R, Houlston R S
Abstract excerpt
Chronic lymphocytic leukemia (CLL) shows evidence of familial aggregation, but the genetic basis is poorly understood. The existence of a linkage between HLA and Hodgkin lymphoma, another B-cell disorder, coupled with the fact that CLL is frequently associated with autoimmune disease, led to the question of whether the major histocompatibility complex (MHC) region is involved in familial cases of CLL. To examine...
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