Article
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.
Cell - 26 Jun 1998
Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, Hirokawa N
Abstract excerpt
Mouse kif5B gene was disrupted by homologous recombination. kif5B-/- mice were embryonic lethal with a severe growth retardation at 9.5-11.5 days postcoitum. To analyze the significance of this conventional kinesin heavy chain in organelle transport, we studied the distribution of major organelle...
Topics
- Animals
- Anti-Bacterial Agents
- Brefeldin A
- Cell Fractionation
- Cell Nucleus
- Cells, Cultured
- Cyclopentanes
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Golgi Apparatus
- Kinesins
- Lysosomes
- Macrolides
- Mice
- Mice, Knockout
- Microtubules
- Mitochondria
- Nocodazole