Article
The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en.
Virology - 20 Jun 1998
Blick T J, Sahasrabudhe A, McDonald M, Owens I J, Morley P J, Fenton R J, McKimm-Breschkin J L
Abstract excerpt
We have previously described a 4-guanidino-Neu5Ac2en (zanamivir)-resistant neuraminidase (NA) variant G70C4-G, with an active site mutation Glu 119 to Gly. This variant has been found to also harbor a hemagglutinin (HA) mutation in the receptor binding site, Ser 186 to Phe. Examination of early p...
Topics
- Animals
- Antiviral Agents
- Cell Line
- DNA Mutational Analysis
- Dogs
- Drug Resistance, Microbial
- Female
- Ferrets
- Genes, Viral
- Guanidines
- Hemagglutinin Glycoproteins, Influenza Virus
- Mice
- Mice, Inbred C57BL
- Mutation
- Neuraminidase
- Orthomyxoviridae
- Orthomyxoviridae Infections
- Pyrans