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Article

The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en.

Virology - 20 Jun 1998

Blick T J, Sahasrabudhe A, McDonald M, Owens I J, Morley P J, Fenton R J, McKimm-Breschkin J L

Abstract excerpt

We have previously described a 4-guanidino-Neu5Ac2en (zanamivir)-resistant neuraminidase (NA) variant G70C4-G, with an active site mutation Glu 119 to Gly. This variant has been found to also harbor a hemagglutinin (HA) mutation in the receptor binding site, Ser 186 to Phe. Examination of early passages of the G70C4-G virus revealed that this HA mutation had arisen by the first passage. From a subsequent passage...

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Identifiers

PMID: 9656997
DOI: 10.1006/viro.1998.9194

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