Article
Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus.
The Journal of infectious diseases - 1 Nov 1998
Gubareva L V, Matrosovich M N, Brenner M K, Bethell R C, Webster R G
Abstract excerpt
Zanamivir, a neuraminidase inhibitor, has shown promise as a drug to control influenza. During prolonged treatment with zanamivir, a mutant virus was isolated from an immunocompromised child infected with influenza B virus. A hemagglutinin mutation (198 Thr-->Ile) reduced the virus affinity for r...
Topics
- Amino Acid Substitution
- Animals
- Antiviral Agents
- Bone Marrow Transplantation
- Cell Line
- Chlorocebus aethiops
- Dogs
- Drug Resistance, Microbial
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay
- Female
- Ferrets
- Guanidines
- Hemagglutination Inhibition Tests
- Humans
- Immunosuppression Therapy
- Infant
- Influenza B virus