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Article

High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene.

Neuroscience letters - 5 Jun 1998

Türker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch K P, Schuster R, Schütz H, Weiler G, Stöber G

Abstract excerpt

Central serotonergic neurotransmission has been implicated in the aetiology of ethanol tolerance and dependence. Cellular expression of the serotonin transporter and serotonin reuptake is modulated via a polymorphic, repetitive element in the 5'-flanking regulatory region of the serotonin transporter gene (5-HTTLPR). We report the association of the low-activity, short variant of the 5-HTTLPR with high ethanol...

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Identifiers

PMID: 9654330
DOI: 10.1016/s0304-3940(98)00347-4

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