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Article

Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair.

Mutation research - 4 Sept 2001

Dunkern T R, Fritz G, Kaina B

Abstract excerpt

Cisplatin is a highly potent cytotoxic and genotoxic agent used in the chemotherapy of various types of tumors. Its cytotoxic effect is supposed to be due to the induction of intra- and interstrand DNA cross-links which are repaired via the nucleotide excision repair (NER) pathway. Here, we elucidated the mechanism of cisplatin-induced cytotoxicity in mutants derived from CHO-9 cells defective in NER. We compared...

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Source

Identifiers

PMID: 11516928
DOI: 10.1016/s0921-8777(01)00095-7

Genes

ERCC1
ERCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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